Convenient synthesis of 3,4-dichloro-5-hydroxy-2(5H)-furanone glycoconjugates.

Straightforward Synthesis of 2(5H)-Furanones as Promising Cross-Coupling Partners: Direct Furanone Annulation Utilizing Ti-Mediated Aldol Addition

Direct 2(5H)-furanone annulation produces promising cross-coupling partners incorporating mor p-bromoand p-tosyloxyphenyl groups into the 5-position of a notable 2(5H)furanone pharmacore. The present one-pot annulation method involves two distinctive reactions: (i) a powerful and crossed Ti-direct aldol addition and (ii) an acid-induced characteristic cyclocondensation, leading to 2(5H)-furanon...

5-hydroxy-3-vinyl-2(5H)-furanone--a new inhibitor of human synovial phospholipase A2 and platelet aggregation from fermentations of a Calyptella species (basidiomycetes).

5-Hydroxy-3-vinyl-2(5H)-furanone, a potent and selective inhibitor of human synovial phospholipase A2 was isolated from fermentations of a Calyptella species. Its structure as identified by spectroscopic methods is identical to PA 147, an antibiotic previously isolated from a streptomycete. 5-hydroxy-3-vinyl-2(5H)-furanone inhibits the aggregation of human and bovine platelets stimulated by dif...

Novel compounds from the mycelia and fruiting bodies of Climacodon septentrionalis.

A novel ester (1) along with a known compound (2) were isolated from the mycelia of Climacodon septentrionalis. A novel furanone (3) and a known compound (4) were purified from the fruiting bodies of the fungus. The respective structures of 1 and 3 were determined as those of (S)-3-p-tolylbutyl 2-hydroxy-2-methylpropanoate and (-)-5-hydroxy-3,4-dimethyl-5-pentylfuran-2(5H)-one by interpreting t...

A CONVENIENT AND GENERAL SYNTHESIS OF THIADIAZOLO [2,3-C] [1,2,4] TRIAZINES

Condensation and cyclization of 5-hydroxy- 1,2,4- thiadiazol-2-yl hydrazine 1 with pyruvic acid, phenacyl bromide, propargyl bromide and ally1 bromide afforded compounds 2,5,7 3, 4 ,6 and 8 respectively, Reaction of 1 with epichforohydrine afforded 4-hydroxy-N-[5-hydroxy- 1 ,3,4-thiadiazoly1] pyrazolidine 9

DRAFT: Evidence on the carcinogenicity of MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone